Compounds
What Is NMN? The NAD+ Precursor Guide for 2026
THE PROBLEM
The supplement industry runs on outdated data and vague claims.
Most supplement "research" is cherry-picked, funded by the brands selling the product, or based on cell studies that never replicated in humans. The compounds that work are buried under the ones with better marketing budgets.
WHAT BRANDS TELL YOU
- Clinically proven formula
- Therapeutic dose
- Premium ingredients
- Backed by science
WHAT THE DATA SAYS
- Based on 1 pilot study with 12 participants
- Dose not matched to any published human RCT
- Generic extract — not the form used in the research
- 3 studies, all funded by the manufacturer
73%
of supplements tested in 2024 had label accuracy issues
< 1%
of standard curcumin absorbed without enhanced delivery
$60B+
US supplement market built on this information gap
OUR APPROACH
6 dimensions. 1 composite score. No opinion involved.
Every compound in the Index is scored across 6 evidence-based dimensions, weighted by their relevance to longevity. The formula is public. The data sources are cited. Nothing is subjective.
Omega-3 (EPA/DHA)
87
Composite Score
Longevity Evidence30%
85
Consistency20%
72
Human RCT Volume15%
95
Mechanistic Depth15%
90
Safety10%
92
Bioavailability10%
70
Every score derived from a public, rigid methodology. No proprietary algorithms. No hidden weights.
THE COMPOUND INDEX
25 compounds. Ranked by evidence.
Each compound scored across 6 evidence-based dimensions. These are the top 5 by composite score. The full Index includes tier placements, scoring breakdowns, key studies, and dosing data for all 25.
#1
87
Omega-3 (EPA/DHA)
Well-Established
#2
82
Vitamin D3
Foundation
#3
78
CoQ10 / Ubiquinol
Evidence-Backed
#4
76
Creatine
Well-Established
#5
74
NMN
Evidence-Backed
THE JOURNAL
111+ articles on the science of aging well.
No product pitches. No sponsored content. Every article cites primary research, defines its terms, and tells you what the evidence actually supports — and where it falls short.
Start Here
Compounds
Aging Science
Practical Guides
PRINCIPLES
What we believe about supplements.
Data over marketing
If a compound does not have human trial data on longevity endpoints, we say so. Clearly. A well-marketed compound with weak evidence scores lower than an obscure one with strong data.
Public methodology
Our scoring formula, data sources, and dimension weights are published. You can check our work. If you disagree with a weight or a data point, tell us.
Updated quarterly
New RCTs publish. Scores change. A compound score from last year is not the same as a score from this year. We re-run the numbers every quarter and publish what changed.
No proprietary blends
We name every compound, every dose, every branded ingredient source. If a supplement brand hides behind a "proprietary blend," ask them what they are hiding and why.
THE COMPOUND INDEX
Every compound scored. Every claim verified.
25 longevity compounds ranked across 6 evidence-based dimensions. Public methodology. Updated quarterly.
6-dimension scoring: longevity evidence, consistency, RCT volume, mechanistic depth, safety, bioavailability
847+ studies analyzed with key RCTs cited for every compound — dosing, form, and timing included
Scores recalculated every quarter as new research publishes — what scored well last year may not today
Compound Index — Quarterly Updates
The scoring changes when the science does.
New compounds added. Scores updated quarterly.