The Compound Index
An evidence-ranked guide to every longevity compound that matters. No marketing. No hype. Just what the data says.
Last updated: Q1 2026
Why not just count studies?
Raw study count is misleading. Most research measures general health, not biological aging.
The Study Count Trap
Vitamin D has 100× more studies. But only ~20 measure aging-specific endpoints.
NMN has 15 human RCTs. 13 are measuring exactly what you care about.
The 6 Scoring Dimensions
Longevity-Specific Endpoints
Does the research measure aging outcomes? NAD+ levels, epigenetic age, senescence — not general health.
Effect Size Consistency
Do independent labs get the same result? Multiple trials, different populations, same direction.
Human RCT Volume
How many randomized controlled human trials exist? Quality weighted over quantity.
Mechanistic Plausibility
Is the aging pathway established? Known targets like sirtuins, mTOR, senescence score higher.
Safety / Tolerability
Adverse event rates, drug interactions, therapeutic window. Higher = safer.
Oral Bioavailability
Does the oral form achieve studied plasma levels? Many compounds fail here.
Every longevity compound, ranked.
Click any tier to explore the compounds within it.
Cutting-edge compounds with early but highly promising lifespan or healthspan data, often from animal models.
Compounds with strong mechanistic plausibility and growing human data, but lacking large-scale long-term trials.
Substances with robust human clinical data demonstrating targeted improvements in aging biomarkers.
Widely studied compounds with decades of human safety data and consistent, reliable healthspan benefits.
Essential nutrients and foundational elements required for baseline cellular function and longevity.
Cutting-edge compounds with early but highly promising lifespan or healthspan data.
Strong mechanistic plausibility and growing human data.
Robust human clinical data demonstrating targeted improvements in aging biomarkers.
Decades of human safety data and consistent, reliable healthspan benefits.
Essential nutrients required for baseline cellular function and longevity.
Ranking Comparison
Two ways to rank supplements.
Toggle between raw study volume and our weighted longevity score. Watch what happens.
Full Methodology
How we score every compound.
For the detail-oriented reader. Expand any section below.
Compounds are evaluated across 6 dimensions, weighted by importance to longevity outcomes:
- Longevity-Specific Endpoints (30%): Scored based on the proportion of trials measuring aging biomarkers (NAD+, epigenetic age, senescence).
- Effect Size Consistency (20%): Evaluates whether independent labs reproduce similar effect sizes in the same direction.
- Human RCT Volume (15%): Raw count of randomized controlled trials, logarithmic scale.
- Mechanistic Plausibility (15%): Alignment with the Hallmarks of Aging (e.g., mTOR, AMPK, Sirtuins).
- Safety / Tolerability (10%): Based on adverse event rates and therapeutic window.
- Oral Bioavailability (10%): Does the standard oral form achieve plasma levels observed in successful trials?
We strictly filter out general health endpoints to focus on biological aging.
QUALIFYING
- • Epigenetic clock deceleration
- • NAD+ metabolome restoration
- • Senescent cell clearance
- • Telomere attrition rate
- • Autophagy induction markers
NON-QUALIFYING
- • General antioxidant capacity
- • Subjective mood/energy
- • Acute sports performance
- • Basic vitamin deficiency correction
Data is aggregated from PubMed, ClinicalTrials.gov, and Examine.com databases.
The index is updated quarterly. Our team manually reviews new RCTs published in the preceding 90 days to adjust scores. Animal data is only considered for Mechanistic Plausibility; all other dimensions require human data.
Disclosure: Daily Compounds is a longevity science company. Some compounds in this index may appear in future Daily Compounds products.
The Compound Index is an independent data project. Scores are calculated using a rigid, public formula. The methodology is applied uniformly — no compound receives preferential treatment.
Disclaimer: This index is for informational purposes only and does not constitute medical advice. Consult a physician before beginning any supplementation protocol.
Compound Index — Quarterly Updates
The scoring changes when the science does.
New compounds added. Scores updated quarterly.
These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult a physician before beginning any supplementation protocol.