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Glycine: The Simplest Amino Acid With the Biggest Longevity Impact (2026)Glycine drives collagen synthesis, glutathione production, and sleep quality. GlyNAC studies show reversal of aging hallmarks. 3-5g/day dose.
GlyNAC: The Glycine + NAC Stack Backed by Human Aging Trials (2026)GlyNAC (glycine + NAC) restored glutathione to young-adult levels and reversed 8+ aging biomarkers in the Baylor RCT. See the full trial breakdown.
Apigenin: CD38 Inhibitor, Sleep Support, and NAD+ Protector (2026)Apigenin inhibits the enzyme destroying your NAD+ while supporting sleep via GABA-A modulation. Explore this underrated longevity compound.
Spermidine + NMN: Can You Stack Them? (2026 Guide)Spermidine triggers autophagy via EP300 inhibition. NMN restores NAD+ via NAMPT. Zero pathway overlap, potential synergy. Full mechanistic breakdown and timing protocol.
Spermidine: The Autophagy Trigger Hiding in Your Diet (2026)Spermidine induces autophagy via AMPK/SIRT1 and EP300 inhibition. Higher intake links to 5+ year mortality reduction. Explore the full science.
Sulforaphane: The Broccoli Compound That Activates Your Body's Defense System (2026)Sulforaphane is the most potent natural Nrf2 activator, controlling 200+ defense genes. See the clinical evidence and sprouts vs. supplements.
Creatine Beyond Muscle: Brain Health, Mitochondria, and Aging (2026)Creatine is the most studied sports supplement — but its longevity story is about brain energy and mitochondria. See what 500+ studies show.
Ergothioneine: The Antioxidant Your Body Stockpiles for a Reason (2026)Your body has a dedicated transporter (OCTN1) that stockpiles ergothioneine in stressed cells. Levels decline with age. Explore the emerging science.
Ergothioneine: The Longevity Vitamin Nobody Knows AboutYour body evolved a dedicated transporter for ergothioneine — evidence it's essential. Levels decline with age. See the 2024 RCT results.
Taurine and Aging: What the Science Actually Says (2026)A 2023 Science paper called taurine an aging driver. A 2025 NIH study challenged that. See what the evidence actually supports.
Rapamycin: The Most Studied Anti-Aging Drug in History (2026)Rapamycin inhibits mTOR and extends lifespan in every organism tested. See the science, human protocols, risks, and 9-14% lifespan extension data.
Metformin for Longevity: What the TAME Trial Will Finally Answer (2026)Metformin is now being tested as the first FDA-recognized anti-aging drug. Explore the TAME trial, AMPK mechanism, and exercise interference.
Berberine and Longevity: The "Nature's Metformin" Claim, Examined (2026)Berberine activates the same longevity enzyme as metformin via a different mechanism. See 46 RCTs, bioavailability data, and what the evidence supports.
Omega-3 and Longevity: Beyond Heart Health (2026)EPA and DHA preserve telomere length, resolve inflammation via SPMs, and maintain brain volume. Your omega-3 index is a key longevity biomarker.
Magnesium and Longevity: The Most Deficient Mineral in the Modern Diet (2026)Up to 50% of Americans lack magnesium – a cofactor in 600+ reactions for ATP, DNA repair, and sleep. Discover the best forms and how to fix it.
Vitamin D and Aging: The Hormone Everyone Is Deficient In (2026)42% of US adults are vitamin D deficient. This hormone affects immune function, bone density, cancer risk, and mortality. Target: 40-60 ng/mL.
Protein, mTOR, and Aging: How Much Protein Actually Optimizes Longevity? (2026)High protein accelerates aging via mTOR — but too little destroys muscle. Learn the science of protein optimization by age, activity, and timing.
Longevity for Women Over 40: Perimenopause, Hormones, and Cellular Aging (2026)Menopause accelerates biological aging by ~6%. Learn how estrogen decline affects mitochondria, NAD+, bones, and brain — and what to do about it.
David Sinclair's Supplement Stack: The Complete 2026 ProtocolSinclair's full 2026 protocol: NMN, resveratrol, berberine, fisetin, rapamycin, and more. What changed, evidence for each, doses.
Longevity Blood Tests: What to Track and Why Your Doctor Doesn't Order Them (2026)The blood biomarkers that predict how fast you're aging – organized into 3 tiers with optimal ranges, action steps, and where to get tested without a referral.
Biological Age Testing: The Complete Guide to Measuring How Fast You're Aging (2026)Epigenetic clocks, blood biomarkers, and at-home tests — measure your biological age and track whether your longevity protocol works.
How to Actually Lower Your Biological Age: A Practical Protocol (2026)A phased, evidence-based protocol for reducing biological age. Covers the Fitzgerald trial (3.23 years reversed), exercise, sleep, and supplements.
Hormesis: Why Small Stresses Make You Age Better (2026)Exercise, fasting, heat, cold, and polyphenols activate repair systems that slow aging. Learn why megadose antioxidants can block these benefits.
Sauna and Longevity: The Complete Guide to Heat Stress for Healthy Aging (2026)4-7 sauna sessions weekly linked to 40% lower all-cause mortality. Explore heat shock proteins, cardiovascular benefits, and the optimal longevity protocol.
Caloric Restriction Mimetics: Compounds That Mimic Fasting Without Fasting (2026)Resveratrol, metformin, spermidine, and berberine activate the same pathways as caloric restriction. Find what works for daily use.
Intermittent Fasting and Longevity Supplements: Complete Timing GuideWhen to take NMN, CoQ10, and senolytics around an IF schedule. Daytime vs evening dosing, whether supplements break a fast, and what the science actually says.
Sleep and Longevity: The Overlooked Pillar (Plus Supplements That Help) (2026)Sleep is the #1 longevity intervention most people ignore. Explore glymphatic clearance, DNA repair, and supplements that support sleep and aging.
Grip Strength and Mortality: The Cheapest Longevity Test You Can Do (2026)Grip strength predicts all-cause mortality better than blood pressure. The PURE study found each 5kg drop = 17% higher mortality. Test yours today.
Strength Training for Longevity: Why Muscle Is a Survival Organ (2026)Muscle secretes longevity-promoting myokines, regulates glucose, and predicts mortality. Get the evidence-based resistance training protocol for aging well.
VO2 Max and Longevity: The Single Best Predictor of How Long You'll Live (2026)Low VO2 max carries 5x higher mortality risk — worse than smoking or diabetes. Learn how to test, benchmark, and improve this longevity metric.
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